Membrane Trafficking and
Organelle Biogenesis

Sorrento, Italy
14-15 October 2018


  • Sunday, 14 October

    13:00-14:00 Registration
    14:00-15:05 Session 1: Organellar tasks in overall cellular homeostasis
    Chair: Simona Paladino (Naples)
    14:00-14:10 Nunzia Mollo (Naples)
    Alterations of mitochondrial biogenesis, dynamics and mitophagy in trisomy 21 cells
    14:10-14:20 Annunziata G. Cicatiello (Naples)
    Intracellular attenuation of thyroid hormone influences energy metabolism by reducing mitochondria biogenesis and inducing mitochondrial dysfunction
    14:20-14:30 Mariano Stornaiuolo (Naples)
    Allosteric control of protein folding in the Endoplasmic Reticulum: endogenous ligands, protein-networks, metabolic switches
    14:30-14:55 Daniela Sarnataro (Naples)
    Regulation of subcompartmental targeting and folding properties of the prion-like protein shadoo
    14:55-15:05 Francesca Zappa (Naples)
    The TRAPP complex modulates the stress response by controlling stress granule composition and functions
    15:05-16:15 Session 2: Fusion, fission and contact sites
    Chair: Daniela Sarnataro (Naples)
    15:05-15:25 Carmen Valente (Naples)
    Molecular mechanisms of BARS-mediated membrane fission
    15:25-15:50 Massimo D’Agostino (Naples)
    A tethering complex drives the terminal stage of SNARE-dependent membrane fusion
    15:50-16:15 Rossella Venditti (Naples)
    Structural and functional regulation of endoplasmic reticulum-Golgi contact sites (ERTGoCS)
    16:15-16:40 Coffee break
    16:40-18:15 Session 3: From the cell surface to the cell interior
    Chair: Paolo Remondelli (Salerno)
    16:40-17:00 Simona Paladino (Naples)
    The complexity of surface organization of GPI-anchored proteins in polarized epithelial cells: an overview
    17:00-17:10 Alexia Conte (Milan)
    Integration of modeling and experiments to define principles of EGFR activation,endocytosis and intracellular signaling
    17:10-17:20 Roberta Romano (Lecce)
    The endocytic pathway is altered in Charcot-Marie-Tooth Type 2B
    17:20-17:30 Katia Cortese (Genoa)
    Crosstalk between extracellular vesicles release and autophagy in ERBB2+ and trastuzumab-resistant breast cancer cells
    17:30-17:40 Lucrezia Zerillo (Naples)
    Alteration of endosomal trafficking is associated with early-onset parkinsonism 20
    17:40-17:50 Flora Guerra (Lecce)
    Role of RAB7A in chemoresistance
    17:50-18:15 Maria Vittoria Barone (Naples)
    Constitutive alterations in vesicular trafficking sensitize the innate immune response to gliadin in patients with celiac disease
    18:20-19:20 Keynote lecture
    Ludger Johannes (Paris, France)
    Lectin-driven and glycosphingolipid-dependent construction of endocytic pits
    19:30 Dinner
  • Monday, 15 October

    8:30-10:40 Session 4: Homeostasis of the secretory pathway
    Chair: Carmen Valente (Naples)
    8:30-8:55 Stephanie Lebreton (Paris, France)
    Calcium levels in the Golgi complex regulate clustering and apical sorting of GPI-APs in epithelia
    8:55-9:05 Maria C. Masone (Naples)
    FAPP1 regulates the activity of the oncogene GOLPH3 by controlling PI4P at the Golgi
    9:05-9:15 Prathyush D. Pothukuchi (Naples)
    Grasp55 regulates glycosphingolipid biosynthesis by controlling the localization of glycosylation enzymes
    9:15-9:25 Valeria Capaci (Trieste)
    A mutant p53/miR-30d axis reprograms cancer cell secretome by disrupting Golgi structure
    9:25-9:50 Advait Subramanian (Naples)
    An autoregolatory signaling system senses cargo at the ER exit sites and regulates the homeostasis of secretion
    9:50-10:10 Eelco van Anken (Milan)
    Secretory pathway stress responses vary according to the nature of the proteostatic insult
    10:10-10:20 Paola Panina (Milan)
    Homeostatic adjustment of the entire secretory pathway during decidualization of endometrial stromal cells
    10:20-10:30 Tiziana Tempio (Milan)
    Physiological effects of zinc-dependent ERp44 regulation in the secretory pathway
    10:30-10:40 Ilaria Sorrentino (Milan)
    Mechanism and consequences of ERp44 cycling
    10:40-11:20 Coffee break
    11:20-13:00 Session 5: The multiple faces of autophagy
    Chair: Eelco van Anken (Milan)
    11:20-11:45 Maurizio Renna (Naples)
    Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis
    11:45-11:55 Francesca Cammarota (Naples)
    The alteration of cardiac phenotype and autophagic flux consequent to HIPK2 deletion in mice
    11:55-12:05 Agnese Secondo (Naples)
    The pharmacological activation of Mucolipin TRP channel 1 (TRPML1) protects motor neurons exposed to the cycad neurotoxin L-BMAA by promoting autophagic clearance
    12:05-12:30 Chiara De Leonibus (Naples)
    Autophagy quality control of procollagen via a Calnexin-FAM134B ER-phagy complex
    12:30-12:40 Valentina Tedeschi (Naples)
    The functional coupling between endoplasmic reticulum and lysosomes for intracellular Ca2+ handling is disrupted in brain ischemia
    12:40-12:50 Laura Cinque (Naples)
    Developmental regulation of lysosome biogenesis shapes cellular identity and function
    12:50-13:00 Closing Remarks