Sunday, 14 October |
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| 13:00-14:00 | Registration |
| 14:00-15:05 | Session 1: Organellar tasks in overall cellular homeostasis Chair: Simona Paladino (Naples) |
| 14:00-14:10 | Nunzia Mollo (Naples) Alterations of mitochondrial biogenesis, dynamics and mitophagy in trisomy 21 cells |
| 14:10-14:20 | Annunziata G. Cicatiello (Naples)
Intracellular attenuation of thyroid hormone influences energy metabolism by reducing mitochondria biogenesis and inducing mitochondrial dysfunction |
| 14:20-14:30 | Mariano Stornaiuolo (Naples)
Allosteric control of protein folding in the Endoplasmic Reticulum: endogenous ligands, protein-networks, metabolic switches |
| 14:30-14:55 | Daniela Sarnataro (Naples)
Regulation of subcompartmental targeting and folding properties of the prion-like protein shadoo |
| 14:55-15:05 | Francesca Zappa (Naples)
The TRAPP complex modulates the stress response by controlling stress granule composition and functions |
| 15:05-16:15 | Session 2: Fusion, fission and contact sites Chair: Daniela Sarnataro (Naples) |
| 15:05-15:25 | Carmen Valente (Naples)
Molecular mechanisms of BARS-mediated membrane fission |
| 15:25-15:50 | Massimo D’Agostino (Naples)
A tethering complex drives the terminal stage of SNARE-dependent membrane fusion |
| 15:50-16:15 | Rossella Venditti (Naples)
Structural and functional regulation of endoplasmic reticulum-Golgi contact sites (ERTGoCS) |
| 16:15-16:40 | Coffee break |
| 16:40-18:15 | Session 3: From the cell surface to the cell interior Chair: Paolo Remondelli (Salerno) |
| 16:40-17:00 | Simona Paladino (Naples)
The complexity of surface organization of GPI-anchored proteins in polarized epithelial cells: an overview |
| 17:00-17:10 | Alexia Conte (Milan)
Integration of modeling and experiments to define principles of EGFR activation,endocytosis and intracellular signaling |
| 17:10-17:20 | Roberta Romano (Lecce)
The endocytic pathway is altered in Charcot-Marie-Tooth Type 2B |
| 17:20-17:30 | Katia Cortese (Genoa)
Crosstalk between extracellular vesicles release and autophagy in ERBB2+ and trastuzumab-resistant breast cancer cells |
| 17:30-17:40 | Lucrezia Zerillo (Naples)
Alteration of endosomal trafficking is associated with early-onset parkinsonism 20 |
| 17:40-17:50 | Flora Guerra (Lecce)
Role of RAB7A in chemoresistance |
| 17:50-18:15 | Maria Vittoria Barone (Naples)
Constitutive alterations in vesicular trafficking sensitize the innate immune response to gliadin in patients with celiac disease |
| 18:20-19:20 | Keynote lecture Ludger Johannes (Paris, France) Lectin-driven and glycosphingolipid-dependent construction of endocytic pits |
| 19:30 | Dinner |
Monday, 15 October |
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| 8:30-10:40 | Session 4: Homeostasis of the secretory pathway Chair: Carmen Valente (Naples) |
| 8:30-8:55 | Stephanie Lebreton (Paris, France) Calcium levels in the Golgi complex regulate clustering and apical sorting of GPI-APs in epithelia |
| 8:55-9:05 | Maria C. Masone (Naples) FAPP1 regulates the activity of the oncogene GOLPH3 by controlling PI4P at the Golgi |
| 9:05-9:15 | Prathyush D. Pothukuchi (Naples) Grasp55 regulates glycosphingolipid biosynthesis by controlling the localization of glycosylation enzymes |
| 9:15-9:25 | Valeria Capaci (Trieste) A mutant p53/miR-30d axis reprograms cancer cell secretome by disrupting Golgi structure |
| 9:25-9:50 | Advait Subramanian (Naples) An autoregolatory signaling system senses cargo at the ER exit sites and regulates the homeostasis of secretion |
| 9:50-10:10 | Eelco van Anken (Milan) Secretory pathway stress responses vary according to the nature of the proteostatic insult |
| 10:10-10:20 | Paola Panina (Milan) Homeostatic adjustment of the entire secretory pathway during decidualization of endometrial stromal cells |
| 10:20-10:30 | Tiziana Tempio (Milan) Physiological effects of zinc-dependent ERp44 regulation in the secretory pathway |
| 10:30-10:40 | Ilaria Sorrentino (Milan) Mechanism and consequences of ERp44 cycling |
| 10:40-11:20 | Coffee break |
| 11:20-13:00 | Session 5: The multiple faces of autophagy Chair: Eelco van Anken (Milan) |
| 11:20-11:45 | Maurizio Renna (Naples) Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis |
| 11:45-11:55 | Francesca Cammarota (Naples) The alteration of cardiac phenotype and autophagic flux consequent to HIPK2 deletion in mice |
| 11:55-12:05 | Agnese Secondo (Naples) The pharmacological activation of Mucolipin TRP channel 1 (TRPML1) protects motor neurons exposed to the cycad neurotoxin L-BMAA by promoting autophagic clearance |
| 12:05-12:30 | Chiara De Leonibus (Naples) Autophagy quality control of procollagen via a Calnexin-FAM134B ER-phagy complex |
| 12:30-12:40 | Valentina Tedeschi (Naples) The functional coupling between endoplasmic reticulum and lysosomes for intracellular Ca2+ handling is disrupted in brain ischemia |
| 12:40-12:50 | Laura Cinque (Naples) Developmental regulation of lysosome biogenesis shapes cellular identity and function |
| 12:50-13:00 | Closing Remarks |